hp66 Protein Paralogs: SUMO Modification and Complex Formation Inaugural-Dissertation
نویسندگان
چکیده
PUBLICATIONS Gong Z, Brackertz M, Renkawitz R. SUMO modification enhances p66 mediated transcriptional repression of the Mi-2/NuRD complex. p66 alpha and p66 beta of the Mi-2/NuRD complex mediated MBD2 and histone interaction.
منابع مشابه
Hugh Davson Distinguished Lectureship of the Cell and Molecular Physiology
Ahner A, Gong X, Frizzell RA. Divergent signaling via SUMO modification: potential for CFTR modulation. Am J Physiol Cell Physiol 310: C175–C180, 2016; doi:10.1152/ajpcell.00124.2015.—The cystic fibrosis transmembrane conductance regulator (CFTR) is generally responsible for the cAMP/PKA regulated anion conductance at the apical membranes of secretory epithelial cells. Mutations in CFTR underli...
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The cystic fibrosis transmembrane conductance regulator (CFTR) is generally responsible for the cAMP/PKA regulated anion conductance at the apical membranes of secretory epithelial cells. Mutations in CFTR underlie cystic fibrosis (CF), in which the most common variant, F508del, causes protein misfolding and its proteasome-mediated degradation. A new pathway that contributes to mutant CFTR degr...
متن کاملSUMOylation and cell signalling.
SUMOylation is a highly transient post-translational protein modification. Attachment of SUMO to target proteins occurs via a number of specific activating and ligating enzymes that form the SUMO-substrate complex, and other SUMO-specific proteases that cleave the covalent bond, thus leaving both SUMO and target protein free for the next round of modification. SUMO modification has major effect...
متن کاملIn vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.
The SUMO-1 has been identified as a protein that is highly similar to ubiquitin and shown to conjugate to RanGAP1, PML, Sp200 and I kappa B alpha. The conjugation steps are thought to be similar to those of ubiquitination; and human Ubc9, which is homologous to the E2 enzyme for the ubiquitin conjugation step, was identified and shown to be necessary for the conjugation of SUMO-1 to its target ...
متن کاملComparative proteomic analysis identifies a role for SUMO in protein quality control.
The small ubiquitin-like modifiers (SUMOs) alter the functions of diverse cellular proteins by covalent posttranslational modification and thus influence many cellular functions, including gene transcription, cell cycle, and DNA repair. Although conjugation by ubiquitin and SUMO-2/3 are largely functionally and mechanistically independent from one another, both appear to increase under conditio...
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تاریخ انتشار 2006